a solution of natural origin

Quatreflora™  is a beneficial live healthy yeast of natural origin.
Quatreflora™ is the brand name of Saccharomyces cerevisiae CNCM I-3856,
an exclusive yeast strain selected and patented by Lesaffre for its superior activity to support vaginal health.

Lesaffre gnosis Quatreflora


Discovered in Lesaffre’s laboratories, Quatreflora™ has been selected by our experts among our collection of strains for its beneficial effect to help manage vaginal discomfort.


Lesaffre’s researchers identified, characterized and registered this specific strain in the CNCM French collection of microorganisms as Saccharomyces cerevisiae CNCM I-3856. It has been protected by several international patents.

Regulatory & Intellectual property requirements vary by country and applications (including claims). We encourage our customers to consult their legal department or counsel before launching the product on the market.


your safe ally
that fits all your diets

Quatreflora™ IS SAFE

  • Quatreflora™ Biotic is a safe solution of natural origin. It can be used every day without side effect, or developing habituation.
  • Quatreflora™ Biotic is also in compliance with authorities’ guidelines (EU Qualified Presumption of Safety & US Generally Recognized as Safe-21 CFR).

Quatreflora™ FITS ALL DIETS*

  • Quatreflora™ can be consumed by women with special diets.

Quatreflora natural

*As for all healthy live yeasts, the use of Quatreflora™ in patients in fragile health conditions (such as high-risk immune-compromised individuals, critically sick infants, pre-term infants…) is contraindicated.

High-quality science

Saccharomyces cerevisiae CNCM I-3856

Saccharomyces cerevisiae CNCM I-3856 may support healthy vaginal flora.


Saccharomyces cerevisiae CNCM I-3856 benefits from:
• several preclinical studies that demonstrated its efficacy and the mechanism of action
• a clinical study on women showing its beneficial effect.


Dr Duncan WILSON, independent expert, International specialist of Candida albicans, Center for medical mycology, University of Aberdeen (UK), says about our preclinical study « a single administration of live S.cerevisiae cells elicited Candida clearance at levels comparable to treatment with the commonly antifungal drug, fluconazole. »
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Candida albicans

Gardnerella vaginalis

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your ally of natural origin
which may support healthy vaginal flora

  • This field is for validation purposes and should be left unchanged.





About us

Backing up on Lesaffre’s experience

Innovative global player in yeast, bacteria and pure molecule from fermentation, Gnosis by Lesaffre provides scientifically-proven and sustainably-sourced active ingredients and solutions to customers in the pharmaceutical, nutritional and functional food industries for a wide range of health benefits.


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Gnosis by Lesaffre is a business unit of Lesaffre.